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The role of Omega-3 and Omega-9 fatty acids for the treatment of neuropathic pain after neurotrauma.

Sensorimotor Function Group, Hospital Nacional de Parapléjicos, SESCAM, 45071 Toledo, Spain. Electronic address: igalan@jccm.es. Sensorimotor Function Group, Hospital Nacional de Parapléjicos, SESCAM, 45071 Toledo, Spain. Electronic address: dserranomu@externas.sescam.jccm.es. GIFTO, Nursing and Physiotherapy Faculty, Universidad de Castilla la Mancha, 45072 Toledo, Spain. Electronic address: julio.soriano@uclm.es. Pharmacology and Nutrition Department, Health Sciences Faculty, Universidad Rey Juan Carlos, 28922 Alcorcón, Madrid, Spain. Electronic address: carlos.goicoechea@urjc.es. Sensorimotor Function Group, Hospital Nacional de Parapléjicos, SESCAM, 45071 Toledo, Spain; Stoke Mandeville Spinal Research, National Spinal Injuries Centre, Buckinghamshire Healthcare NHS Trust, HP21 8AL Aylesbury, UK; Harris Manchester College, OX1 3TD University of Oxford, UK. Electronic address: jscott@sescam.org. Instituto de Neurociencias de Castilla y León, 37007 Salamanca, Spain. Electronic address: anvecri@usal.es. Sensorimotor Function Group, Hospital Nacional de Parapléjicos, SESCAM, 45071 Toledo, Spain. Electronic address: gavila@sescam.jccm.es.

Biochimica et biophysica acta. Biomembranes. 2017;(9 Pt B):1629-1635
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Abstract

Omega-3 polyunsaturated fatty acids (PUFAs), such as docosaexaenoic acid (DHA) and eicosapentaenoic acid (EPA), mediate neuroactive effects in experimental models of traumatic peripheral nerve and spinal cord injury. Cellular mechanisms of PUFAs include reduced neuroinflammation and oxidative stress, enhanced neurotrophic support, and activation of cell survival pathways. Bioactive Omega-9 monounsaturated fatty acids, such as oleic acid (OA) and 2-hydroxy oleic acid (2-OHOA), also show therapeutic effects in neurotrauma models. These FAs reduces noxious hyperreflexia and pain-related anxiety behavior following peripheral nerve injury and improves sensorimotor function following spinal cord injury (SCI), including facilitation of descending inhibitory antinociception. The relative safe profile of neuroactive fatty acids (FAs) holds promise for the future clinical development of these molecules as analgesic agents. This article is part of a Special Issue entitled: Membrane Lipid Therapy: Drugs Targeting Biomembranes edited by Pablo V. Escribá.

Methodological quality

Publication Type : Review

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